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Year Number of Results
1998 2
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2000 3
2001 5
2002 2
2003 1
2004 2
2005 3
2006 3
2007 2
2008 3
2009 3
2010 2
2013 3
2014 4
2015 6
2016 2
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2018 1
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52 results

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Page 1
Energy substrate metabolism, mitochondrial structure and oxidative stress after cardiac ischemia-reperfusion in mice lacking UCP3.
Sánchez-Pérez P, Mata A, Torp MK, López-Bernardo E, Heiestad CM, Aronsen JM, Molina-Iracheta A, Jiménez-Borreguero LJ, García-Roves P, Costa ASH, Frezza C, Murphy MP, Stenslokken KO, Cadenas S. Sánchez-Pérez P, et al. Free Radic Biol Med. 2023 Aug 20;205:244-261. doi: 10.1016/j.freeradbiomed.2023.05.014. Epub 2023 Jun 8. Free Radic Biol Med. 2023. PMID: 37295539 Free article.
As both mechanisms might be protective following IR injury, we investigated functional, mitochondrial structural, and metabolic cardiac remodeling in wild-type mice and in mice lacking UCP3 (UCP3-KO) after IR. Results showed that infarct size in isolated perfused he …
As both mechanisms might be protective following IR injury, we investigated functional, mitochondrial structural, and metabolic cardiac remo …
TNF-α and cancer cachexia: Molecular insights and clinical implications.
Patel HJ, Patel BM. Patel HJ, et al. Life Sci. 2017 Feb 1;170:56-63. doi: 10.1016/j.lfs.2016.11.033. Epub 2016 Dec 3. Life Sci. 2017. PMID: 27919820 Review.
A number of pro-inflammatory cytokines, like interleukin-1 (IL-1), IL-6, tumor necrosis factor- alpha (TNF-alpha) may have important role in the pathological mechanisms of cachexia in cancer. ...It has been associated with the formation of IL-1 and increases the uncoupling …
A number of pro-inflammatory cytokines, like interleukin-1 (IL-1), IL-6, tumor necrosis factor- alpha (TNF-alpha) may have important …
Thermogenic protein UCP1 and UCP3 expression in non-small cell lung cancer: relation with glycolysis and anaerobic metabolism.
Giatromanolaki A, Balaska K, Kalamida D, Kakouratos C, Sivridis E, Koukourakis MI. Giatromanolaki A, et al. Cancer Biol Med. 2017 Nov;14(4):396-404. doi: 10.20892/j.issn.2095-3941.2017.0089. Cancer Biol Med. 2017. PMID: 29372106 Free PMC article.
UCP1 was significantly associated with squamous cell histology (P = 0.05), whilst UCP3 was more frequently overexpressed in large cell carcinomas (P = 0.08), and was inversely related to necrosis (P = 0.009). ...Kaplan-Meier survival analysis showed that UCP3 …
UCP1 was significantly associated with squamous cell histology (P = 0.05), whilst UCP3 was more frequently overexpressed in large cel …
Hypoadiponectinemia-induced upregulation of microRNA449b downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury in diabetic mice.
Meng Z, Liang B, Wu Y, Liu C, Wang H, Du Y, Gan L, Gao E, Lau WB, Christopher TA, Lopez BL, Koch WJ, Ma X, Zhao F, Wang Y, Zhao J. Meng Z, et al. J Mol Cell Cardiol. 2023 Sep;182:1-14. doi: 10.1016/j.yjmcc.2023.06.004. Epub 2023 Jul 10. J Mol Cell Cardiol. 2023. PMID: 37437402
Venn analysis followed by luciferase assay identified Nrf-1 and Ucp3 as the two most important miR-449b targets. In vivo administration of anti-miR-449b in APN-KO mice attenuated MI/R-stimulated superoxide overproduction. ...Conclusion: We demonstrated for the first time t …
Venn analysis followed by luciferase assay identified Nrf-1 and Ucp3 as the two most important miR-449b targets. In vivo administrati …
Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling.
Dhingra R, Margulets V, Chowdhury SR, Thliveris J, Jassal D, Fernyhough P, Dorn GW 2nd, Kirshenbaum LA. Dhingra R, et al. Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):E5537-44. doi: 10.1073/pnas.1414665111. Epub 2014 Dec 8. Proc Natl Acad Sci U S A. 2014. PMID: 25489073 Free PMC article.
This coincided with mitochondrial localization of Bnip3, increased reactive oxygen species production, loss of mitochondrial membrane potential, mitochondrial permeability transition pore opening, and necrosis. Interestingly, a 3.1-fold decrease in maximal mitochondrial re …
This coincided with mitochondrial localization of Bnip3, increased reactive oxygen species production, loss of mitochondrial membrane potent …
In the rat, tumor necrosis factor alpha administration results in an increase in both UCP2 and UCP3 mRNAs in skeletal muscle: a possible mechanism for cytokine-induced thermogenesis?
Busquets S, Sanchís D, Alvarez B, Ricquier D, López-Soriano FJ, Argilés JM. Busquets S, et al. FEBS Lett. 1998 Dec 4;440(3):348-50. doi: 10.1016/s0014-5793(98)01485-9. FEBS Lett. 1998. PMID: 9872400 Free article.
Since the discovery of the new members of the UCP (uncoupling protein) family, UCP2 and UCP3, very few studies have dealt with the regulation of their expression. Bearing this in mind, administration of a single intravenous injection of TNF-alpha (100 microg/kg body weight …
Since the discovery of the new members of the UCP (uncoupling protein) family, UCP2 and UCP3, very few studies have dealt with the re …
Possible physiological roles of mitochondrial uncoupling proteins--UCPn.
Jezek P. Jezek P. Int J Biochem Cell Biol. 2002 Oct;34(10):1190-206. doi: 10.1016/s1357-2725(02)00061-4. Int J Biochem Cell Biol. 2002. PMID: 12127570 Review.
Five mitochondrial uncoupling proteins exist in the human gemone: UCP2, expressed ubiquitously; UCP1, exclusively in brown adipose tissue (BAT); UCP3, predominantly in muscle; UCP4 and BMCP (UCP5), in brain. UCP4 is the ancestral prototype from which the other UCPn diverge …
Five mitochondrial uncoupling proteins exist in the human gemone: UCP2, expressed ubiquitously; UCP1, exclusively in brown adipose tissue (B …
Induction of fatty acid translocase/CD36, peroxisome proliferator-activated receptor-gamma2, leptin, uncoupling proteins 2 and 3, and tumor necrosis factor-alpha gene expression in human subcutaneous fat by lipid infusion.
Nisoli E, Carruba MO, Tonello C, Macor C, Federspil G, Vettor R. Nisoli E, et al. Diabetes. 2000 Mar;49(3):319-24. doi: 10.2337/diabetes.49.3.319. Diabetes. 2000. PMID: 10868951
Using reverse transcriptase-polymerase chain reaction analysis, the mRNA expression of fatty acid translocase (FAT)/CD36, PPAR-gamma2, leptin, uncoupling protein (UCP)-2 and UCP-3, and tumor necrosis factor (TNF)-alpha was investigated in gluteal subcutaneous fat biopsies …
Using reverse transcriptase-polymerase chain reaction analysis, the mRNA expression of fatty acid translocase (FAT)/CD36, PPAR-gamma2, lepti …
Increased gene expression of brown fat uncoupling protein (UCP)1 and skeletal muscle UCP2 and UCP3 in MAC16-induced cancer cachexia.
Bing C, Brown M, King P, Collins P, Tisdale MJ, Williams G. Bing C, et al. Cancer Res. 2000 May 1;60(9):2405-10. Cancer Res. 2000. PMID: 10811117

By contrast, UCP2 mRNA levels in skeletal muscle were comparably increased in both MAC16 and pair-fed groups (respectively, 183 and 163% above controls; both, P < 0.05), with no significant difference between these two groups. Similarly, UCP3 mRNA was significantly high

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By contrast, UCP2 mRNA levels in skeletal muscle were comparably increased in both MAC16 and pair-fed groups (respectively, 183 and 163% abo …
Chronic Hyperinsulinemia Causes Selective Insulin Resistance and Down-regulates Uncoupling Protein 3 (UCP3) through the Activation of Sterol Regulatory Element-binding Protein (SREBP)-1 Transcription Factor in the Mouse Heart.
Harmancey R, Haight DL, Watts KA, Taegtmeyer H. Harmancey R, et al. J Biol Chem. 2015 Dec 25;290(52):30947-61. doi: 10.1074/jbc.M115.673988. Epub 2015 Nov 10. J Biol Chem. 2015. PMID: 26555260 Free PMC article.
We and others have shown previously that mitochondrial uncoupling protein 3 (UCP3) improves functional recovery of the rodent heart during reperfusion. ...Sustained down-regulation of cardiac UCP3 by hyperinsulinemia may partly explain the poor prognosis of type 2 d …
We and others have shown previously that mitochondrial uncoupling protein 3 (UCP3) improves functional recovery of the rodent heart d …
52 results